BDBM50640925 CHEMBL5574272

SMILES C[C@H](c1c(cncc1Cl)Cl)Oc2cc(ncc2C#N)NC(=O)Nc3c(cc(c(n3)C=O)CN4CCN(CC4=O)C)OCCN5CCOCC5

InChI Key InChIKey=AEFSLXKVONEDJJ-UHFFFAOYSA-N

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50640925   

TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50640925BDBM50640925(CHEMBL5574272)
Affinity DataIC50: 13nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50640925BDBM50640925(CHEMBL5574272)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal 6His tagged FGFR4 (unknown origin) expressed in Escherichia coli (DE3) (NEB) using Tyr04 peptide as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50640925BDBM50640925(CHEMBL5574272)
Affinity DataIC50: 57nMAssay Description:Inhibition of FGFR4 V550M mutant (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50640925BDBM50640925(CHEMBL5574272)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed