BDBM50642996 CHEMBL5575673

SMILES c1ccc2c(c1)nnn2C(=O)N3CCC(CC3)N4[C@@H]([C@H](C4=O)c5cccc(c5)F)c6ccc7c(c6)OCO7

InChI Key InChIKey=ZYBYLXKHKPMAIL-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50642996   

TargetMonoglyceride lipase(Mouse)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50642996BDBM50642996(CHEMBL5575673)
Affinity DataIC50: 0.0490nMAssay Description:Inhibition of mouse MAGL using arachidonic acid as substrate preincubated with compound for 30 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50642996BDBM50642996(CHEMBL5575673)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human MAGLMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50642996BDBM50642996(CHEMBL5575673)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human recombinant MAGL (1 to 303 residues) expressed in human HeLa cells using 2-arachidonoylglycerol as substrate preincubated with co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Rat)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50642996BDBM50642996(CHEMBL5575673)
Affinity DataIC50: 592nMAssay Description:Inhibition of rat MAGL expressed in human HeLa cells using 2-arachidonoylglycerol as substrate preincubated with compound for 20 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed