BDBM50645888 CHEMBL5590777

SMILES Cn1ccc(n1)C2CC(C2)N(c3cc(c(cc3F)NC(=O)C4=CC=NN(C4=O)c5ccc(cn5)F)F)c6c7ccnn7ccn6

InChI Key InChIKey=JZBISQRYUUZSEV-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50645888   

TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645888BDBM50645888(CHEMBL5590777)
Affinity DataIC50: 5nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET Y1230H mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645888BDBM50645888(CHEMBL5590777)
Affinity DataIC50: 6nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET D1228N mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645888BDBM50645888(CHEMBL5590777)
Affinity DataIC50: 23nMAssay Description:Inhibition of MET D1228N mutant (unknown origin) transfected in mouse NIH3T3 cells incubated for 1 hr by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645888BDBM50645888(CHEMBL5590777)
Affinity DataIC50: 90nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET F1200I mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)