BDBM50652799 CHEMBL5661898
SMILES Cc1ccc(cc1)NC(=O)NCCC[N@](C[C@@H]2[C@H]([C@H]([C@@H](O2)n3cnc4c3ncnc4N)O)O)C(C)C
InChI Key InChIKey=KQTSVJQPAVOUSL-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50652799
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University of Toronto
Curated by ChEMBL
University of Toronto
Curated by ChEMBL
Affinity DataKd: 2.70nMAssay Description:Binding affinity to recombinant N-terminal DOT1L (1 to 420 residues) (unknown origin) expressed in Escherichia coli (DE3) assessed as dissociation co...More data for this Ligand-Target Pair
3D Structure (crystal)TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University of Toronto
Curated by ChEMBL
University of Toronto
Curated by ChEMBL
Affinity DataKd: 27nMAssay Description:Binding affinity to recombinant N-terminal DOT1L (1 to 420 residues) (unknown origin) expressed in Escherichia coli (DE3) assessed as dissociation co...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University of Toronto
Curated by ChEMBL
University of Toronto
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant N-terminal DOT1L (1 to 420 residues) (unknown origin) expressed in Escherichia coli (DE3) using [3H]-SAM as substrate prein...More data for this Ligand-Target Pair