BDBM507742 1-(7-chloro-1-(3-fluorophenyl)-2-oxo- 1,2-dihydroquinazolin-4-yl)azetidine-3- carbonitrile::US11046691, Compound 82::US11084798, Cpd No 82::US11130759, Cpd. No. 82

SMILES Fc1cccc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N1CC(C1)C#N

InChI Key InChIKey=KDUZUFWUAWCHLM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 507742   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507742(1-(7-chloro-1-(3-fluorophenyl)-2-oxo- 1,2-dihydroq...)
Affinity DataIC50: <200nMAssay Description:Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507742(1-(7-chloro-1-(3-fluorophenyl)-2-oxo- 1,2-dihydroq...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507742(1-(7-chloro-1-(3-fluorophenyl)-2-oxo- 1,2-dihydroq...)
Affinity DataIC50: <200nMAssay Description:5 μL of 3× final concentration test compounds in DMSO or DMSO were transferred to the appropriate wells of a microtiter plate and the plate was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent