BDBM508350 1-(3-chloropyridin-2-yl)-7-(1,1- difluoroethyl)-4-(methylamino)- quinazolin-2(1H)-one::US11046691, Compound 661::US11084798, Cpd No 661::US11130759, Cpd. No. 661

SMILES CNc1nc(=O)n(-c2ncccc2Cl)c2cc(ccc12)C(C)(F)F

InChI Key InChIKey=JBBVYFAUELHRPJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 508350   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508350(1-(3-chloropyridin-2-yl)-7-(1,1- difluoroethyl)-4-...)
Affinity DataIC50: <200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508350(1-(3-chloropyridin-2-yl)-7-(1,1- difluoroethyl)-4-...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508350(1-(3-chloropyridin-2-yl)-7-(1,1- difluoroethyl)-4-...)
Affinity DataIC50: <200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent