BDBM510419 (5R,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy-8- ((3-hydroxyazetidin- 1-yl)methyl)-5,6,7,8- tetrahydroquinoline- 5-carboxamide::US11077100, Example 279

SMILES OC1CN(C[C@@]2(O)CC[C@](F)(C(=O)NCc3ccc(Cl)cc3Cl)c3cccnc23)C1

InChI Key InChIKey=YXWXGZFXJJWCIA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 510419   

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510419((5R,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydrox...)
Affinity DataIC50: 50nMAssay Description:1. Wash each well with 80 microL of assay buffer (20 mM HEPES, 1×HBSS, pH 7.4 adjusted with NaOH) three times and leave 20 microL using plate washer,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510419((5R,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydrox...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human P2X7 receptor transfected in HEK293 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM510419((5R,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydrox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat P2X7 receptor transfected in HEK293 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed