BDBM510427 (5S,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy-8 ((methylthio)methyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide::US11077100, Example 287::US11439633, Example 287

SMILES CSC[C@]1(O)CC[C@@](F)(C(=O)NCc2ccc(Cl)cc2Cl)c2cccnc12

InChI Key InChIKey=OUMBZWQWTIEJIG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510427   

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510427((5S,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydro...)
Affinity DataIC50: 50nMAssay Description:1. Wash each well with 80 microL of assay buffer (20 mM HEPES, 1×HBSS, pH 7.4 adjusted with NaOH) three times and leave 20 microL using plate washer,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
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TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510427((5S,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydro...)
Affinity DataIC50: 50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent