BDBM510839 1-phenyl-3-({(aR)- 6-[6-(3,3,3- trifluoropropoxy) pyrazolo[1,5- a]pyridine-3- amido]spiro[3.3] heptan-2-yl}oxy)-1H- pyrazole-4- carboxamide::US11078197, Example 16

SMILES NC(=O)c1cn(nc1O[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2cnn3c(C4CC4)c(OCCC(F)(F)F)ccc23)C1)-c1ccccc1

InChI Key InChIKey=WVMVQQHNUYBJGO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 510839   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510839(1-phenyl-3-({(aR)- 6-[6-(3,3,3- trifluoropropoxy) ...)
Affinity DataIC50: 1.37E+5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent