BDBM510907 5-{[(aR)-6-(4-benzyl-2,6- dioxopiperazin-1- yl)spiro[3.3]heptan- 2-yl]oxy}thieno[3,2- b]pyridine-6- carboxamide::US11078197, Example 86::US11673886, Example 86

SMILES NC(=O)c1cc2sccc2nc1O[C@H]1C[C@]2(C1)C[C@@H](C2)N1C(=O)CN(Cc2ccccc2)CC1=O

InChI Key InChIKey=RSPIGCFUEJBOBV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510907   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510907(5-{[(aR)-6-(4-benzyl-2,6- dioxopiperazin-1- yl)spi...)
Affinity DataIC50: 8.59E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510907(5-{[(aR)-6-(4-benzyl-2,6- dioxopiperazin-1- yl)spi...)
Affinity DataIC50: 85.9nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent