BDBM510909 2-{[(aR)-6-[3- (cyanomethyl) benzamido] spiro[3.3]heptan- 2-yl]oxy}- 5H,7H,8H- pyrano[4,3- b]pyridine-3- carboxamide::US11078197, Example 88::US11673886, Example 88

SMILES NC(=O)c1cc2COCCc2nc1O[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2cccc(CC#N)c2)C1

InChI Key InChIKey=QNQHLADPPWCPQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510909   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510909(2-{[(aR)-6-[3- (cyanomethyl) benzamido] spiro[3.3]...)
Affinity DataIC50: 3.50E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510909(2-{[(aR)-6-[3- (cyanomethyl) benzamido] spiro[3.3]...)
Affinity DataIC50: 35nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent