BDBM510916 2,3-dimethyl-5- {[(aR)-6-(3- cyanobenzamido) spiro[3.3]heptan-2- yl]oxy}thieno[3,2- b]pyridine-6- carboxamide::US11078197, Example 95::US11673886, Example 95

SMILES Cc1sc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4cccc(c4)C#N)C3)nc2c1C

InChI Key InChIKey=NUFXZBBBXMAYQC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510916   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510916(2,3-dimethyl-5- {[(aR)-6-(3- cyanobenzamido) spiro...)
Affinity DataIC50: 79nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
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TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510916(2,3-dimethyl-5- {[(aR)-6-(3- cyanobenzamido) spiro...)
Affinity DataIC50: 7.90E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent