BDBM510925 1-cyclopropyl-3- {[(aR)-6-(4-benzyl-2,5- dioxoimidazolidin- 1-yl)spiro[3.3]heptan- 2-yl]oxy}-1H- pyrazole-4- carboxamide::US11078197, Example 104::US11673886, Example 104

SMILES NC(=O)c1cn(nc1O[C@H]1C[C@]2(C1)C[C@@H](C2)N1C(=O)NC(Cc2ccccc2)C1=O)C1CC1

InChI Key InChIKey=ADTRFGKMLAEMBO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510925   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510925(1-cyclopropyl-3- {[(aR)-6-(4-benzyl-2,5- dioxoimid...)
Affinity DataIC50: 2.04E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510925(1-cyclopropyl-3- {[(aR)-6-(4-benzyl-2,5- dioxoimid...)
Affinity DataIC50: 2.04E+6nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent