BDBM511303 2-Fluoro-1-(1-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-3-(tetrahydrofuran-3-yl)-5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl)ethan-1-one::US11058688, Example 4

SMILES Cn1cc(cn1)-c1nn(C)c2ccc(cc12)-c1nc(C2CCOC2)n2CCN(Cc12)C(=O)CF

InChI Key InChIKey=DNPQLQWTVARREM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511303   

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 511303BDBM511303(2-Fluoro-1-(1-(1-methyl-3-(1-methyl-1H-pyrazol-4-y...)
Affinity DataIC50: 1.26E+3nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 511303BDBM511303(2-Fluoro-1-(1-(1-methyl-3-(1-methyl-1H-pyrazol-4-y...)
Affinity DataIC50: 1.54E+4nMAssay Description:The binding of 2.5 nM of BRD4(49-170) to 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) was assessed following the same procedure described for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent