BDBM511414 5-(1-(7-acetyl-3- cyclopropyl-5,6,7,8- tetrahydroimidazo[1,5- a]pyrazin-1-yl)-1,2,3,4- tetrahydroquinolin-6-yl)- 1-methylpyridin-2(1H)- one::US11058688, Example 113

SMILES CC(=O)N1CCn2c(C3CC3)nc(N3CCCc4cc(-c5ccc(=O)[nH]c5)ccc43)c2C1

InChI Key InChIKey=NKTDWQAYWBMPAR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511414   

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 511414BDBM511414(5-(1-(7-acetyl-3- cyclopropyl-5,6,7,8- tetrahydroi...)
Affinity DataIC50: 193nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 511414BDBM511414(5-(1-(7-acetyl-3- cyclopropyl-5,6,7,8- tetrahydroi...)
Affinity DataIC50: 3.46E+3nMAssay Description:The binding of 2.5 nM of BRD4(49-170) to 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) was assessed following the same procedure described for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent