BDBM511420 1-(1-(6-(1-cyclobutyl-1H- pyrazol-4-yl)-3,4- dihydroquinolin-1(2H)- yl)-3-cyclopropyl-5,6- dihydroimidazo[1,5- a]pyrazin-7(8H)-yl)ethan- 1-one::US11058688, Example 119

SMILES CC(=O)N1CCn2c(nc(N3CCCc4cc(ccc34)-c3cnn(c3)C3CCC3)c2C1)C1CC1

InChI Key InChIKey=LBNVFIAAXXAQHO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511420   

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 511420BDBM511420(1-(1-(6-(1-cyclobutyl-1H- pyrazol-4-yl)-3,4- dihyd...)
Affinity DataIC50: 313nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 511420BDBM511420(1-(1-(6-(1-cyclobutyl-1H- pyrazol-4-yl)-3,4- dihyd...)
Affinity DataIC50: 2.50E+4nMAssay Description:The binding of 2.5 nM of BRD4(49-170) to 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) was assessed following the same procedure described for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent