BDBM511429 ((1R,3R)-1-amino-3-(4-(1-((cyclopropylmethoxy)imino)ethyl)phenyl)cyclopentyl)methyl Dihydrogen Phosphate::US11059784, Example 38

SMILES C\C(=N/OCC1CC1)c1ccc(cc1)[C@@H]1CC[C@](N)(COP(O)(O)=O)C1

InChI Key InChIKey=NFXUGCUSODTQII-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 511429   

TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM511429(((1R,3R)-1-amino-3-(4-(1-((cyclopropylmethoxy)imin...)
Affinity DataIC50: 284nMAssay Description:Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1×109 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
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TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM511429(((1R,3R)-1-amino-3-(4-(1-((cyclopropylmethoxy)imin...)
Affinity DataEC50: >3.00E+4nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in an 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or ED...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM511429(((1R,3R)-1-amino-3-(4-(1-((cyclopropylmethoxy)imin...)
Affinity DataEC50: >3.00E+4nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in an 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or ED...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent