BDBM513333 US11091471, Example RE-A::US20240270744, Example RE-A::US20240279218, Example RE-A

SMILES Cc1onc(c1COc1ccc(nn1)C(=O)NC1CCOCC1)-c1cccnc1

InChI Key InChIKey=JAUWZXFLIUKTGH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 513333   

LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  1.5nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  2.80nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  6.84nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  35.6nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  65nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetIntegrin alpha-5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  65nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  179nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  276nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM513333(US11091471, Example RE-A | US20240279218, Example ...)
Affinity DataKi:  1.02E+4nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent