BDBM517113 2-((4-(2-fluoro-4-(2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamido)phenoxy)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)-2-methylpropyl hydrogen sulfate::US11104676, Example 183

SMILES CC(C)(COS(O)(=O)=O)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12

InChI Key InChIKey=OKAOCZFXIWPEHE-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 517113   

TargetHepatocyte growth factor receptor [Y1230C](Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 10.5nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 13.1nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
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TargetHepatocyte growth factor receptor [D1228N](Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 14.3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
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TargetHepatocyte growth factor receptor [F1200I](Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 14.8nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
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TargetHepatocyte growth factor receptor [Y1230S](Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 16.6nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor [Y1230H](Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 24.2nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor [1-13,15-1390](Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 26.4nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor [D1228H](Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 34.1nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor [L1195V](Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 339nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 5.40E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 1.80E+4nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Array Biopharma

US Patent
LigandPNGBDBM517113(US11104676, Example 183 | 2-((4-(2-fluoro-4-(2-(4-...)
Affinity DataIC50: 1.09E+5nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent