BDBM518061 4-[(2R)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-8-[4-[2-fluoroethyl(methyl) amino]cyclohexoxy]-2,3-dihydro-1,4-benzoxazepin-5-one::US11111237, Example 199::US11725001, Example 199

SMILES CN(CCF)C1CCC(CC1)Oc1ccc2c(OCCN(C[C@H](O)CN3CCc4ccccc4C3)C2=O)c1

InChI Key InChIKey=QLJRHNGGYYZMBX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518061   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM518061(US11111237, Example 199 | 4-[(2R)-3-(3,4-dihydro-1...)
Affinity DataIC50: 50nMAssay Description:The histone H4 peptide was diluted with carbonate-bicarbonate buffer and prepared to 100 μg/mL, and then dispensed onto the plate per 100 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM518061(US11111237, Example 199 | 4-[(2R)-3-(3,4-dihydro-1...)
Affinity DataIC50: 50nMAssay Description:Experimental procedure: The histone H4 peptide was diluted with carbonate-bicarbonate buffer and prepared to 100 μg/mL, and then dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent