BDBM520572 (3R,6R,7S,8E,22S)-6′-Chloro-7-[2-[(3R,4S)-3,4-difluoropyrrolidin-1-yl]ethoxy]-12,12-dimethyl-15,15-dioxo-spiro[11,20-dioxa-15-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16,18,24-tetraene-22,1′-tetralin]-13-one::US11130769, Ex. No. 269

SMILES CC1(C)OC\C=C\[C@H](OCCN2C[C@H](F)[C@H](F)C2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)S(=O)(=O)NC1=O

InChI Key InChIKey=XNSJIZHBCJMRDA-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 520572   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM520572(US11130769, Ex. No. 269 | (3R,6R,7S,8E,22S)-6̸...)
Affinity DataKi: <300nMAssay Description:The assay was carried out in black half-area 96-well NBS plate (Corning), containing 15 nM of MCL-1 (BPS Bioscience), 5 nM of FITC-Bim and 3-fold ser...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent