BDBM520995 (+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]quinolin-4-yl}carbonyl)amino]-4-(2-chlorophenyl)pentanoic acid (Enantiomer 1)::US11149018, Example 275
SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1ccccc1Cl)N1CCCC1
InChI Key InChIKey=YQOLEILXOBUDMU-KRWDZBQOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 520995
Affinity DataKi: 16nMAssay Description:Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillati...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Antagonist activity at recombinant full-length human TP receptor expressed in HEK293 cells assessed as inhibition of U-44069-induced response measure...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 15 mins in presence of NADPH generating system by LC-MS/MS...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 15 mins in presence of NADPH generating system by LC-MS/M...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 15 mins in presence of NADPH generating system by LC-MS/MS...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]PGD2 from full-length recombinant human IP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation co...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]PGD2 from full-length recombinant human DP1 receptor expressed in Chem-1 cell membranes measured after 120 mins by scintillation ...More data for this Ligand-Target Pair
Affinity DataIC50: >9.40E+3nMAssay Description:Displacement of [3H]prostaglandin E2 from full-length recombinant human EP4 receptor expressed in HEK293 cell membranes measured after 120 mins by sc...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]prostaglandin E2 from full-length recombinant human EP3 receptor expressed in HEK293 cell membranes measured after 120 mins by sc...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by sc...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]prostaglandin E2 from full-length recombinant human EP1 receptor expressed in HEK293 cell membranes measured after 60 mins by sci...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillati...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at rat FPR stably expressed in CHO cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Antagonist activity at FPR in Wistar rat assessed as inhibition of PGF2alpha-induced uterus contractionMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine product...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]PGD2 from full-length recombinant human CRTH2 receptor expressed in CHOK1 cell membranes measured after 120 mins by scintillation...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 15 mins in presence of NADPH generating system by LC...More data for this Ligand-Target Pair