BDBM521918 US11155557, Example 8::methyl 2-[3-[5- (difluoromethoxy)benzothiophen- 6-yl]-4-(pyrazolo[1,5- a]pyrimidine-3- carbonylamino)pyrazol-1- yl]acetate

SMILES COC(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc2sccc2cc1OC(F)F

InChI Key InChIKey=FJHYGWSXWJKAFQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 521918   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521918(US11155557, Example 8 | methyl 2-[3-[5- (difluorom...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521918(US11155557, Example 8 | methyl 2-[3-[5- (difluorom...)
Affinity DataKi:  0.320nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent