BDBM523963 US11136329, Compound 57::ethyl 2-(2-((1-methyl-1H- pyrazol-4-yl)amino)-7H- pyrrolo[2,3-d]pyrimidin-7- yl)acetate

SMILES CCOC(=O)Cn1ccc2cnc(Nc3cnn(C)c3)nc12

InChI Key InChIKey=AFDWNCAYZREDML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 523963   

TargetTyrosine-protein kinase JAK2(Human)
Vimalan Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 523963BDBM523963(US11136329, Compound 57 | ethyl 2-(2-((1-methyl-1H...)
Affinity DataIC50: 550nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Vimalan Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 523963BDBM523963(US11136329, Compound 57 | ethyl 2-(2-((1-methyl-1H...)
Affinity DataIC50: 5.50E+3nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Vimalan Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 523963BDBM523963(US11136329, Compound 57 | ethyl 2-(2-((1-methyl-1H...)
Affinity DataIC50: 5.50E+3nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent