BDBM523963 US11136329, Compound 57::ethyl 2-(2-((1-methyl-1H- pyrazol-4-yl)amino)-7H- pyrrolo[2,3-d]pyrimidin-7- yl)acetate

SMILES CCOC(=O)Cn1ccc2cnc(Nc3cnn(C)c3)nc12

InChI Key InChIKey=AFDWNCAYZREDML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 523963   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Vimalan Biosciences

US Patent
LigandPNGBDBM523963(US11136329, Compound 57 | ethyl 2-(2-((1-methyl-1H...)
Affinity DataIC50:  5.50E+3nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vimalan Biosciences

US Patent
LigandPNGBDBM523963(US11136329, Compound 57 | ethyl 2-(2-((1-methyl-1H...)
Affinity DataIC50:  5.50E+3nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vimalan Biosciences

US Patent
LigandPNGBDBM523963(US11136329, Compound 57 | ethyl 2-(2-((1-methyl-1H...)
Affinity DataIC50:  550nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent