BDBM523986 US11136329, Compound 95::ethyl 2-(4-((7-(3- acrylamidobenzyl)-7H- pyrrolo[2,3-d]pyrimidin- 2-yl)amino)-1H-pyrazol- 1-yl)acetate

SMILES CCOC(=O)Cn1cc(Nc2ncc3ccn(Cc4cccc(NC(=O)C=C)c4)c3n2)cn1

InChI Key InChIKey=HIGWEXQEAYSZLH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 523986   

TargetTyrosine-protein kinase JAK1(Human)
Vimalan Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 523986BDBM523986(US11136329, Compound 95 | ethyl 2-(4-((7-(3- acryl...)
Affinity DataIC50: 550nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Vimalan Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 523986BDBM523986(US11136329, Compound 95 | ethyl 2-(4-((7-(3- acryl...)
Affinity DataIC50: 550nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Vimalan Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 523986BDBM523986(US11136329, Compound 95 | ethyl 2-(4-((7-(3- acryl...)
Affinity DataIC50: 550nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent