BDBM525521 US11174245, # I-199

SMILES Cn1cc(cn1)-c1cc(ccn1)C(=O)\N=c1/[nH]c2cc(CC#N)ccc2n1CC(C)(C)O

InChI Key InChIKey=ABTHBGGHEGAVLT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 525521   

TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525521(US11174245, # I-199)
Affinity DataIC50: 6.80nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor [695-1022](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525521(US11174245, # I-199)
Affinity DataIC50: 1.52E+3nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent