BDBM526543 Isomer-2: 1-acryloyl-N-(3-(((2-((3-hydroxycyclohexyl)amino)-8-isopropyl pyrazolo[1,5-a][1,3,5]triazin-4-yl)amino)methyl)phenyl)pyrrolidine-3- carboxamide::US11186576, Compound 13.

SMILES CC(C)c1cnn2c(NCc3cccc(NC(=O)C4CCN(C4)C(=O)C=C)c3)nc(N[C@H]3CCC[C@H](O)C3)nc12

InChI Key InChIKey=MPRGZJIDIZHMNQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 526543   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 526543BDBM526543(Isomer-2: 1-acryloyl-N-(3-(((2-((3-hydroxycyclohex...)
Affinity DataIC50: 650nMAssay Description:The ability of compounds to inhibit CDK7 kinase activity was tested in a TR-FRET assay using 5 nM of CDK7/CycH/MNAT1 obtained from Invitrogen, USA. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent