BDBM526627 (1,4-cis)-4-acrylamido-N-(3-(((8-isopropyl-2-((tetrahydrofuran-3-yl)oxy)pyrazolo [1,5-a][1,3,5]triazin-4-yl)amino)methyl)phenyl)cyclohexane-1-carboxamide::US11186576, Compound 100.

SMILES C=CC(=O)N[C@H]1CC[C@@H](C(=O)Nc2cccc(CNc3nc(OC4CCOC4)nc4c(C(C)C)cnn34)c2)CC1

InChI Key InChIKey=WGVBJIOWQJASCQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 526627   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 526627BDBM526627((1,4-cis)-4-acrylamido-N-(3-(((8-isopropyl-2-((tet...)
Affinity DataIC50: 650nMAssay Description:The ability of compounds to inhibit CDK7 kinase activity was tested in a TR-FRET assay using 5 nM of CDK7/CycH/MNAT1 obtained from Invitrogen, USA. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent