BDBM526663 1-acryloyl-N-(3-(((8-isopropyl-2-methoxypyrazolo[1,5-a][1,3,5]triazin-4-yl) amino)methyl)phenyl)piperidine-4-carboxamide::US11186576, Compound 136.

SMILES COc1nc(NCc2cccc(NC(=O)C3CCN(CC3)C(=O)C=C)c2)n2ncc(C(C)C)c2n1

InChI Key InChIKey=ZSEPOSLDBYTTOP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 526663   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 526663BDBM526663(1-acryloyl-N-(3-(((8-isopropyl-2-methoxypyrazolo[1...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of compounds to inhibit CDK7 kinase activity was tested in a TR-FRET assay using 5 nM of CDK7/CycH/MNAT1 obtained from Invitrogen, USA. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent