BDBM527793 (Saxial,R)-8-(8-(2,3- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine::US11179397, Example 10::US11179397, Example 11

SMILES Cc1nc(N2CCC3(CCC[C@H]3N)CC2)n2ccnc2c1-c1cccc(Cl)c1Cl

InChI Key InChIKey=BVXGWNZXOHOJQM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 527793   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527793((Saxial,R)-8-(8-(2,3- dichlorophenyl)-7- methylimi...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527793((Saxial,R)-8-(8-(2,3- dichlorophenyl)-7- methylimi...)
Affinity DataIC50: 52nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent