BDBM527855 (R)-8-(8-((2,3- dichlorophenyl) amino)imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine::US11179397, Example 72

SMILES N[C@@H]1CCCC11CCN(CC1)c1ncc(Nc2cccc(Cl)c2Cl)c2nccn12

InChI Key InChIKey=YPDANYQOODNUNL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527855   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527855((R)-8-(8-((2,3- dichlorophenyl) amino)imidazo[1,2-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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