BDBM527862 (R)-8-(8- (cyclohexylthio) imidazo[1,2-c] pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine::US11179397, Example 79

SMILES N[C@@H]1CCCC11CCN(CC1)c1ncc(SC2CCCCC2)c2nccn12

InChI Key InChIKey=JEGSCSVDAXJOOT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527862   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527862((R)-8-(8- (cyclohexylthio) imidazo[1,2-c] pyrimidi...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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