BDBM527866 (R)-8-(8- ([1,2,4]triazolo[4,3- a]pyridin-8- ylthio)imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan-1- amine::US11179397, Example 83

SMILES N[C@@H]1CCCC11CCN(CC1)c1ncc(Sc2cccn3cnnc23)c2nccn12

InChI Key InChIKey=RQNXJJAFKJMDSM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527866   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527866((R)-8-(8- ([1,2,4]triazolo[4,3- a]pyridin-8- ylthi...)
Affinity DataIC50: 150nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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