BDBM530187 Preparation of 4-[2-(difluoromethyl)-3,3-difluoro-2-methyl-propanoyl]-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile (Example 268) and 4-[2-(difluoromethyl)-3,3-difluoro-2-methyl-butanoyl]-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile (Example 269)::US11203600, Example 268::US11203600, Example 269

SMILES CC(F)(F)C(C)(C(F)F)C(=O)N1CCOc2c(C1)cncc2C#N

InChI Key InChIKey=BFYVUBNMBWAMFR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 530187   

TargetReceptor-interacting serine/threonine-protein kinase 1 [8-327](Human)
Denali Therapeutics

US Patent
LigandPNGBDBM530187(Preparation of 4-[2-(difluoromethyl)-3,3-difluoro-...)
Affinity DataIC50: 550nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1 [8-327](Human)
Denali Therapeutics

US Patent
LigandPNGBDBM530187(Preparation of 4-[2-(difluoromethyl)-3,3-difluoro-...)
Affinity DataIC50: 550nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
Go to US Patent