BDBM531187 2-(4-(5-(5-(((2,3-dihydrobenzofuran-4-yl)methyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8- yl)pyridin-2-yl)piperazin-1-yl)ethanol::US11207325, Example 110

SMILES OCCC1CCN(CCc2ccc(cn2)-c2cnc(NCc3cccc4OCCc34)n3cnnc23)CC1

InChI Key InChIKey=LYOFYQHRLNMKFX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 531187   

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531187BDBM531187(US11207325, Example 110 | 2-(4-(5-(5-(((2,3-dihydr...)
Affinity DataIC50: 9.30nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531187BDBM531187(US11207325, Example 110 | 2-(4-(5-(5-(((2,3-dihydr...)
Affinity DataIC50: 15.2nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531187BDBM531187(US11207325, Example 110 | 2-(4-(5-(5-(((2,3-dihydr...)
Affinity DataIC50: 124nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent