BDBM531225 N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(1-isopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)- [1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 148

SMILES CC(C)n1cc(c(n1)C(F)(F)F)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=OJEVEQVEKLNTSJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 531225   

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531225BDBM531225(US11207325, Example 148 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5.20nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531225BDBM531225(US11207325, Example 148 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 18nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531225BDBM531225(US11207325, Example 148 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 25.2nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent