BDBM531236 N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(1-(2-methoxyethyl)- 3,5-dimethyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 159

SMILES COCCn1nc(C)c(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)c1C

InChI Key InChIKey=QQNPDWBNYQVGAI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531236   

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531236BDBM531236(US11207325, Example 159 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531236BDBM531236(US11207325, Example 159 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 10.3nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent