BDBM532292 JGS79C::N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide::US11208696, Example 11
SMILES CCc1cccc(CC)c1NC(=O)c1ccn-2c1CCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21
InChI Key InChIKey=HGEIUFJVGHMGRR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 532292
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center
US Patent
Netherlands Translational Research Center
US Patent
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center
US Patent
Netherlands Translational Research Center
US Patent
Affinity DataIC50: 4.70nMAssay Description:Displacement of tracer K9 from NanoLuc-fused MPS1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center
US Patent
Netherlands Translational Research Center
US Patent
Affinity DataIC50: 0.600nMAssay Description:Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center
US Patent
Netherlands Translational Research Center
US Patent
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full length TTK (unknown origin) using MBP-derived peptide as substrate preincubated for 1 hr in dark followed by substrate addition an...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center
US Patent
Netherlands Translational Research Center
US Patent
Affinity DataIC50: <1nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair