BDBM535117 Preparation of (2S,4R)-4-fluoro-1-(4-fluorophenylsulfonyl)-N-((5-methoxy-2-(2-(trifluoromethyl)pyrimidin-5-yl)pyridin-4-yl)methyl)pyrrolidine-2-carboxamide::US11236046, Example 196

SMILES COc1cnc(cc1CNC(=O)[C@@H]1C[C@@H](F)CN1S(=O)(=O)c1ccc(F)cc1)-c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=FJBYXALKFQSAGN-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535117   

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Genentech

US Patent

LigandBDBM535117(Preparation of (2S,4R)-4-fluoro-1-(4-fluorophenyls...)Copy SMILESCopy InChI

Affinity DataIC50: 134nMAssay Description:IC50s (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2022
Entry Details
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