BDBM535154 N-{[1-({[(1R)-1-(4-chlorophenyl)-2- [(4-chlorophenyl)methyl]-5-(2- hydroxypropan-2-yl)-3-oxo-2,3- dihydro-1H-isoindol-1- yl]oxy}methyl)cyclopropyl]methyl} methanesulfonamide::US11236047, Example 19

SMILES CCC1(CO[C@]2(N(Cc3ccc(Cl)cc3)C(=O)c3cc(ccc23)C(C)(C)O)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=ONXUOCISKNKLEO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535154   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535154BDBM535154(N-{[1-({[(1R)-1-(4-chlorophenyl)-2- [(4-chlorophen...)
Affinity DataIC50: 2.70nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535154BDBM535154(N-{[1-({[(1R)-1-(4-chlorophenyl)-2- [(4-chlorophen...)
Affinity DataIC50: 22nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent