BDBM535207 (3R)-3-(4-chlorophenyl)-2-[(1S)-1- (4-chlorophenyl)ethyl]-3-{[(3R,4S)-4- hydroxyoxolan-3-yl]oxy}-6-(2- hydroxypropan-2-yl)-2,3-dihydro-1H- isoindol-1-one::US11236047, Example 46::US20230338337, Example 46

SMILES C[C@H](N1C(=O)c2cc(ccc2[C@]1(O[C@@H]1COC[C@@H]1O)c1ccc(Cl)cc1)C(C)(C)O)c1ccc(Cl)cc1

InChI Key InChIKey=JLJRDOGQKDSPHW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 535207   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535207BDBM535207((3R)-3-(4-chlorophenyl)-2-[(1S)-1- (4-chlorophenyl...)
Affinity DataIC50: 16nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535207BDBM535207((3R)-3-(4-chlorophenyl)-2-[(1S)-1- (4-chlorophenyl...)
Affinity DataIC50: 1.08E+4nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535207BDBM535207((3R)-3-(4-chlorophenyl)-2-[(1S)-1- (4-chlorophenyl...)
Affinity DataIC50: 1.08E+4nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent