BDBM535267 (3R)-3-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-6-(2- hydroxypropan-2-yl)-3-(2- methanesulfonylethoxy)-2,3-dihydro- 1H-isoindol-1-one::US11236047, Example 94::US11236047, Example 95

SMILES CCC(O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ccc(cc3)C#N)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=ZOWAIYZZMIRJLG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535267   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535267BDBM535267((3R)-3-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 60nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535267BDBM535267((3R)-3-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 100nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent