BDBM535269 (3R)-3-(4-Chlorophenyl)-2-[(4- chlorophenyl)methyl]-3-{[1- (hydroxymethyl)cyclobutyl]methoxy}- 6-(2-hydroxypropan-2-yl)-2,3- dihydro-1H-isoindol-1-one::US11236047, Example 32

SMILES CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cc1)[C@@]2(OCC1(CO)CCC1)c1ccc(Cl)cc1

InChI Key InChIKey=OYVZDYIWPZZTME-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535269   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535269BDBM535269((3R)-3-(4-Chlorophenyl)-2-[(4- chlorophenyl)methyl...)
Affinity DataIC50: 1.20nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent