BDBM535278 5-chloro-2-{[(1R)-1-(4-chlorophenyl)- 1-ethoxy-7-fluoro-5-[(1S)-1-hydroxy- 1-(oxan-4-yl)propyl]-3-oxo-2,3- dihydro-1H-isoindol-2- yl]methyl}benzoic acid- (tris(hydroxymethyl)aminomethane salt)::US11236047, Example 118

SMILES CCO[C@]1(N(Cc2ccc(Cl)cc2C([O-])=O)C(=O)c2cc(cc(F)c12)[C@](O)(CC)C1CCOCC1)c1ccc(Cl)cc1

InChI Key InChIKey=DLUFTCNJNCOQGS-UHFFFAOYSA-M

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535278   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535278BDBM535278(5-chloro-2-{[(1R)-1-(4-chlorophenyl)- 1-ethoxy-7-f...)
Affinity DataIC50: 34nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent