BDBM535305 6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-(2-hydroxypropan-2-yl)-3-oxo-1- {[(trans-3- hydroxycyclobutyl]methoxy}-2,3- dihydro-1H-isoindol-2- yl]methyl}pyridine-3-carbonitrile::US11236047, Example 419

SMILES CC(C)(O)c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OC[C@H]1C[C@H](O)C1)c1ccc(Cl)cc1

InChI Key InChIKey=BMTZOKAZWFZZTA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535305   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535305BDBM535305(6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-(2-hydroxy...)
Affinity DataIC50: 18nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent