BDBM535315 (2S)-3-{[(1R)-1-(4-Chlorophenyl)-2- [(5-chloropyridin-2-yl)methyl]-7-fluoro- 5-(2-hydroxypropan-2-yl)-3-oxo-2,3- dihydro-1H-isoindol-1-yl]oxy}-2- methylpropanamide::US11236047, Example 167

SMILES C[C@@H](CO[C@]1(N(Cc2ccc(Cl)cn2)C(=O)c2cc(cc(F)c12)C(C)(C)O)c1ccc(Cl)cc1)C(N)=O

InChI Key InChIKey=BQIHMGXSJXBAHX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535315   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535315BDBM535315((2S)-3-{[(1R)-1-(4-Chlorophenyl)-2- [(5-chloropyri...)
Affinity DataIC50: 11nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent