BDBM535323 (3R)-6-[1-(4-aminopiperidin-1-yl)-2- hydroxypropan-2-yl]-3-(4- chlorophenyl)-2-[(5-chloropyridin-2- yl)methyl]-3-methoxy-2,3-dihydro-1H- isoindol-1-one::US11236047, Example 259::US20230338337, Compound 259

SMILES CO[C@]1(N(Cc2ccc(Cl)cn2)C(=O)c2cc(ccc12)C(C)(O)CN1CCC(N)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=YWQGLDHZKOMWAR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535323   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535323BDBM535323((3R)-6-[1-(4-aminopiperidin-1-yl)-2- hydroxypropan...)
Affinity DataIC50: 9.70nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535323BDBM535323((3R)-6-[1-(4-aminopiperidin-1-yl)-2- hydroxypropan...)
Affinity DataIC50: 9.70nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent