BDBM535328 (3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-6-(2- hydroxy-1-{4H,5H,6H,7H- [1,2,3]triazolo[1,5-a]pyrazin-5- yl}propan-2-yl)-3-methoxy-2,3- dihydro-1H-isoindol-1-one::US11236047, Example 262::US20230338337, Compound 262

SMILES CO[C@]1(N(Cc2ccc(Cl)cn2)C(=O)c2cc(ccc12)C(C)(O)CN1CCn2nncc2C1)c1ccc(Cl)cc1

InChI Key InChIKey=VHIUFRHFXUUDAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535328   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 535328BDBM535328((3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 33nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 535328BDBM535328((3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 33nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent