BDBM535366 (3S)-3-(4-chlorophenyl)-3-[(1R)-1- (4-chlorophenyl)-7-fluoro-5-[1-(4- fluoro-1-methylpiperidin-4-yl)-1- hydroxypropyl]-1-methoxy-3-oxo- 2,3-dihydro-1H-isoindol-2- yl]propanoic acid::US11236047, Example 131

SMILES CCC(O)(c1cc2C(=O)N([C@@H](CC(O)=O)c3ccc(Cl)cc3)C(OC)(c2c(F)c1)c1ccc(Cl)cc1)C1(F)CCN(C)CC1

InChI Key InChIKey=UASWWYBCWGDNKX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535366   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535366BDBM535366((3S)-3-(4-chlorophenyl)-3-[(1R)-1- (4-chlorophenyl...)
Affinity DataIC50: 92nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent