BDBM535369 1-({[(1R)-1-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-7-fluoro-5- [1-hydroxy-1-(1-methylpiperidin-4- yl)ethyl]-3-oxo-2,3-dihydro-1H- isoindol-1- yl]oxy}methyl)cyclopropane-1- carboxamide Ex. 305 is the slower eluting isomer::US11236047, Example 305

SMILES CN1CCC(CC1)C(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cn3)[C@](OCC3(CC3)C(N)=O)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=KMIRBOKBTSMCMR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535369   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535369BDBM535369(1-({[(1R)-1-(4-chlorophenyl)-2-[(5- chloropyridin-...)
Affinity DataIC50: 1.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent